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Phospholipase A2: A Potential Therapeutic Target in Inflammation and Cancer (In silico, In vitro, In vivo and Clinical Approach)

Abstract

Nagendra sastry Yarla, Koduri Satyakumar, Duppalapudi Srinivasu, Kaladhar DSVGK, Gjumrakch Aliev, Gangappa Dharmapuri, Goutham Raju SP Swathi Putta, Srinivas Jagarlapoodi, Vemareddy Bheeram and Govinda Rao Duddukuri

Phospholipase A2 (PLA2) (EC 3.1.1.4) is the initial enzyme of arachidonic acid cascade, has key role in inflammation and cancer. Hence, PLA2 inhibitors have wide medicinal importance. This short review focused on PLA2 structure, function and role in inflammation and cancer. Further we tried to collect PLA2 inhibitors from the previous literature and explained the possibility of their utility as anti-inflammatory and anticancer agents.