獣医科学と技術

Pharmacokinetics of Orbifloxacin in Mehsana Goats after Intravenous and Intramuscular Administration

Abstract

Ghanshyam D, Avinash, Divyesh K, Madhavi A, Bhavesh C, Hitesh P and Shailesh M

Single-dose pharmacokinetics of orbifloxacin (2.5 mg/kg bodyweight) were determined in clinically normal female mehsana goats (n=6) following intravenous and intramuscular administration. Orbifloxacin concentrations were determined by high performance liquid chromatography with ultraviolet detection. The concentration–time data were analyzed by non-compartmental kinetic method. Following a single intravenous injection, an elimination half-life (t1/2β) of 8.63 ± 0.130 h. Steady-state volume of distribution (Vdss) and total body clearance (ClB) were 2.99 ± 0.038 L/kg and 0.187 ± 0.002 L/kg/h, respectively. Following intramuscular administration, the elimination rate constant (β), the area under the curve from zero to infinity (AUC0-∞) and the mean absorption time (MAT) were 0.019 ± 0.001 h-1, 19.66 ± 0.216 μg·h/mL and 7.618 ± 0.549 h, respectively. The peak plasma concentration (Cmax) of 1.76 ± 0.010 μg/mL was achieved at 1.00 ± 0.00 h. The mean residence time (MRT) was 21.07 ± 0.478 h and the absolute bioavailability were 155.5 ± 2.487%, respectively. Orbifloxacin could be useful for the treatment of bacterial infections in goats that are sensitive to this drug.