臨床症例報告ジャーナル

Oxidative Stress after Iron Supplementation in Crohn's Disease

Abstract

Marcia Morandi Varela Junqueira-Franco, Carolina Ferreira Nicoletti, Carla Barbosa Nonino, Hélio Vannucchi and Julio Sergio Marchini

Crohn’s disease is a chronic inflammatory intestinal disease associated with increased of pro-inflammatory cytokines, iron deficiency and anaemia. This case report demonstrates a strategy for intravenous iron supplementation in a patient with Crohn´s disease and severe anaemia. This study found an increased in iron and haemoglobin concentrations, malondialdehyde and superoxide dismutase levels and a reduction in glutathione peroxidase (GPx), vitamin A and E. In conclusion the use of intravenous iron probably leads to increase ROS production; this effect may be reduced by using polivitaminics, and enhanced the free radical scavenger.