心血管疾患と診断

NT Pro-BNP can be used as a Risk Predictor of Clinical Atrial Fibrillation with or without Left Atrial Enlargement

Abstract

Zhao X, Li H, Liu C, Ren Y and Sun C

Background: NT Pro-BNP is a blood marker secreted from myocardial. The main stimulus for cardiac NT Pro- BNP secretion is myocardial stretch. NT Pro-BNP is a significant risk factor for stroke of cardiac insufficiency and pulmonary embolism. Patients with normal levels of NT–pro-BNP have low risks for death. So, does atrial stretch occur when patients have atrial fibrillation? Whether atrial fibrillation accompanied by changes in atrial muscle stretch may lead to NT Pro-BNP increase is unknown. The purpose of this experiment is to explore the relationship between NT Pro-BNP and atrial fibrillation.

Hypothesis: Atrial fibrillation may cause changes in atrial muscle stretch. Change of myocardial stretch may lead to NT Pro-BNP secretion increase. We hypothesized that NT Pro-BNP might be increased in AF with or without LAD enlargement.

Methods: Atrial fibrillation may cause changes in atrial muscle stretch. Change of myocardial stretch may lead to NT Pro-BNP secretion increase. We hypothesized that NT Pro-BNP might be increased in AF with or without LAD enlargement.

Results: We draw the results that NT Pro-BNP have a statistical relationship with the occurrence of atrial fibrillation after adjusting age, gender, left atrial diameter, hypertension, diabetes, coronary heart diseases and cerebral infarction.

Conclusion: The NT Pro-BNP of AF group is significantly higher than that of non-AF group with or without left atrial enlargement.