Daniel Mau, Joy Xu and Alexandra Neagu
Although cancer is recognized as an evolutionary process, cancer research lacks focus regarding the disease’s evolutionary aspect. The focus of this study is on metastatic cancer as it is difficult to treat and control. COBWEB, an agent-based simulation software, was used to determine whether adaptive therapy could control the evolutionary trajectory of the tumor and reduce further metastasis in a patient. Initial results indicated that I. drug usage could serve as a selective pressure against aggressive and resistant cells in order to extrapolate selective advantages for the less aggressive cancerous cells and that II. primitive adaptive therapy, based on the oscillation of two drugs, could provide more control over metastasis rather than conventional treatments. Overall, further research is necessary to confirm whether adaptive therapy can increase median survival rates and the quality of life for patients with metastatic cancer.
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