免疫生物学ジャーナル

Kounis Syndrome in a Patient Following Astrazeneca COVID-19 Vaccination

Abstract

Asif Mohamed Farook and Dilshan Priyankara

Kounis syndrome also known as allergic angina syndrome is defined as the occurrence of an acute coronary syndrome concomitantly with hypersensitivity reaction. It was first described in 1991 by Kounis and Zavras. It is a rare syndrome and is often an under diagnosed phenomenon as physicians are unaware of the condition. We discuss a 54 years old female Sri Lankan patient who developed Kounis syndrome following Oxford Astra Zeneca COVID-19 vaccination. The patient initially developed anaphylaxis following the Astra Zeneca COVID-19 vaccine and subsequently developed acute coronary syndrome secondary to anaphylaxis. Patient was treated appropriately and eventually recovered from her condition. This syndrome should be suspected when there is concurrent acute coronary syndrome with allergic reactions. Care givers should be aware of its pathophysiology as treatment of either of the two may worsen the other injury.