法医学ジャーナル

免疫グロブリン受容体と抗原Cは慢性肝拒絶反応のリスクを高める

Abstract

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??????CR???????????????????????????????????KIR/HLA-I??????????????NK????????????????????????????????????????CR??????????????????????KIR???HLA?????????????????????PCR-SSO????????513???????????KIR????????C?HLA-C??????KIR?????????KIR/HLA????????????CR?n=35??????????NCR=478????????????????rKIR2DS2+???rKIR2DS3+????????KIR?aKIR?????CR???NCR??????????????p=0.013???p=0.038????rKIR2DL2+???????KIR?iKIR?????CR???????????????????9.1%?3.7%?p=0.020??KIR2DL3?CR???????????13.1%?5.2%?p=0.008??NCR??????????????CR?HLA-I??MM?????????????d?HLA-C2?????dC2−?????????????????????CR?????????13.1%?5.6%?p=0.018?? rKIR2DL3+/dC1−(p=0.015)?rKIR2DS4/dC1−(p=0.014)?rKIR2DL3+/rKIR2DS4+/dC1−(p=0.006)?CR??????????????

??? 5 ? 10 ???rKIR2DS1+rKIR2DS4+/dC1- ????????????????????????????rKIR/dHLA-C ??? aKIR ?????? CR ? KIR2DS1+/C1-???????????????KIR2DS4+/C1-??????????????????????????