心血管疾患と診断

Heart Regeneration: What can we learn from zebrafish?

Abstract

Mohammadali Badri

Zebrafish is widely becoming more and more useful model to study heart regeneration due to fast re-growing of both myocardial and epicardial cells. Therefore, the regenerative capacity and such genetic tractability in zebrafish encouraged scientists to use this model for their stud-ies. The cheap supply of zebrafish for laboratories also add another reason to use zebrafish rather other animal models.

A new transgenic zebrafish line model added a new approach to understand the underlying signalling pathways requiring for cardiac regeneration. Therefore, this model also provided an extensive genetic fate map for cardiac cell arrangement during cardiac regeneration.

Here in this review, the attempt has been made to elucidate three major injury models in zebrafish and analysing how zebrafish model can potentially become a permanent solution for establishing a new platform for cardiac regenerative medicine