エイズと臨床研究のジャーナル

Favourable Outcome of a Pregnancy with a Maraviroc-Containing Regimen

Abstract

Vincent Jeantils, Ahmed Tigazin, Eric Lachassine, Anabela Rodrigues, Michelle Bentata and Gilles Peytavin

In developed countries, recommendations do exist concerning the use of highly active antiretroviral therapy during pregnancy of HIV positive women. The choice is easy when the mother is infected with a wild virus or in case of only few genotypic mutations; when multiple genotypic resistances are present or in case of a poor adherence, the treatment choice is more difficult. Concerns exist about the use of new available drugs in pregnancy regarding transplacental passage and foetal toxicity. We report here the first case of the use of CCR5 inhibitor-containing regimen during pregnancy.