看護とケアのジャーナル

Expression of Survivin Gene and Protein in Mycosis Fungoides

Abstract

Hanan Nada*, Laila Rashed and Solafa Amin

Background: Survivin is a member of the inhibitors of apoptosis gene family that has been implicated in cell division and suppression of apoptosis that becomes expressed in human cancers, e.g. colorectal, bladder cancers. But, there is no available data on the role of survivin in cutaneous neoplasms.

Aim: To estimate the expression of survivin gene and protein in Mycosis Fungoides (MF).

Methods: Seventeen cases of MF have been en-rolled into this study. Skin biopsies from such patient were subjected to RT-PCR technique to detect the level of survivin gene and protein.

Results: There was significant increase in expression of surviving gene and protein in cases of MF if compared to normal control.

Conclusion: Survivin may have a role in induction of MF and this may influence the therapeutic strategies for the treatment of MF.