法医学研究ジャーナル

Examining the Biochemical and Toxicological Effects of Insulin Overdose in Rats: Insights from a Forensic Angle

Abstract

Arias Francesco

Insulin overdose is a critical concern in forensic investigations due to its potential lethality and widespread availability. This mini-review explores the biochemical and toxicological effects of insulin overdose in rats, offering insights from a forensic perspective. By examining relevant literature, this article elucidates the mechanisms of insulin toxicity, including hypoglycemia, neurologic impairment, and cardiovascular complications. Additionally, it discusses forensic considerations such as postmortem findings, analytical techniques for insulin detection, and interpretation challenges in forensic pathology. Understanding the intricacies of insulin overdose in animal models provides valuable insights for forensic scientists and medical examiners in cases involving suspected insulin-related fatalities.