生物分析および生物医学ジャーナル

Effects of Concurrent Administration of Meloxicam on Pharmacokinetic Parameters of Enrofloxacin in Turkeys

Abstract

Reetu Toppo, B.K.Roy and Anil K.Mishra

The pharmacokinetic studies of enrofloxacin was conducted in eighteen turkeys (1 to 1.5 years age) weighing between 3 to 4 kg following single i.v. dose (10 mg/kg b.w.) alone and with meloxicam (1 mg/kg b.w.). Quantitative estimation of enrofloxacin and meloxicam was done by high performance liquid chromatography. The maximum concentration of drug in plasma (Cp_max) of enrofloxacin with meloxicam (8.42 ± 0.40 μg/ml) was not significantly different from that of enrofloxacin alone (9.68 ± 0.44 μg/ml). Pharmacokinetic parameters of enrofloxacin alone (C°p =10.38±0.43 μg/ml, t_½β =2.73±0.12 h, MRT = 3.65±0.21 h, Cl_B =8.41±0.66 ml/kg/min, Vd_area =1.95±0.08 L/kg) as compared to when it was administered with meloxicam ( C°p =9.35±0.62 μg/ml, t_½β =2.70±0.13 h, MRT =3.73±0.18 h, ClB =9.79±0.84 ml/kg/min, Vd_area =2.26±0.15 L/kg) in turkeys did not differ significantly.

The t_½β of meloxicam with enrofloxacin (2.50±0.08 h) was significantly shorter as compared to meloxicam alone (3.03±0.18 h). Based on pharmacokinetic studies ENR may be injected at dose rate of 4.5 mg/kg i.v. at an interval of 20.38 h in turkeys.