臨床研究ジャーナル

Effect of Voglibose on Circadian Pattern of Blood Glucose and Enzymatic Antioxidants in Normal Rats

Abstract

Naresh K. Reddy, A. Pramod, P. Goverdhan and M. Hariprasad

Aim of the study was to investigate the effect of voglibose on circadian pattern of blood glucose and enzymatic antioxidants in normal rats. Male albino wistar rats were selected, divided into eight groups, each group consist of six animals and subjected for investigation. Voglibose suppressed the postprandial rise of blood glucose in rats, when voglibose (0.3 mg/kg) was given 0.5hr before the administration of carbohydrates such as sucrose, maltose and starch (2 gm/kg each). Blood samples were collected from both the normal and treated animals at o hr, 1hr, 2 hr, 4 hr, 6 hr, and 8 hr respectively. This study showed that the treatment of rats with voglibose significantly suppressed the increase in plasma glucose level after loading with sucrose, maltose and starch at time intervals CT 1400 (8 pm) was significantly lower, against the time CT 2000 (2 am), CT and 0200 (8 am), CT 0800 (2 pm) and circadian pattern of antioxidants in normal rats before and after treatment with voglibose did not show any significant difference at time intervals 0200 CT (8 am), 0800 CT (2 pm), 1400 CT (8 pm), and 2000 CT (2 am).