医療微生物学と診断

Effect of GXM (Glucuronoxylomannan) on the Inflammatory Response in Lung Infection Caused by Cryptococcus neoformans (Serotype A) in Immunodeficient Murine Model (BALB/c-SCID)

Abstract

Eriques Gonçalves Silva, Sandra Marilia de Souza Silva, Claudete Rodrigues Paula and Luciana da Silva Ruiz

GXM (glucuronoxylomannan) is the major component surrounding the capsule of Cryptococcus neoformans having multiple biological functions, one of them and most important, the reduction in production of inflammatory cytokines. They were evaluated in this study the correlation of the production GXM with TNF, IL-6, IL-10, as well, as survival in murine model (BALB-c) and severe combined immunodeficiency (SCID). The animals were infected intravenously with 0.1 ml of a suspension containing 3.0 × 106 model, BALB-c compared to the model. The high production GXM as well as the induction of viable cells of C. neoformans. There was an increase in the production of GXM, as well as a decrease in survival in (SCID) a severe inflammatory response in this model may be due to a compromised immune system.