高血圧ジャーナル: オープンアクセス

Distribution of Angiotensin Converting Enzyme Gene I/D Polymorphism in Normotensive University Students

Abstract

Zair Candido Oliveira Netto, Elisangela da S. Souza, Fabiano Salgueirosa, Ricardo Cunha, Luiz Cesar Guarita- Souza, Rossana Simeoni B, JulioFrancisco C, Francisco Javier López Román and Julio Cesar Bassan

Objectives: The aim of our study was to evaluate frequency ACE I/D polymorphism with control of hypertension in the no athlete population.

Method: A total of 72 University normotensive students (aged 22 ± 1.2 years) were included in the study. DNA extraction from was collected through buccal swabs and was used the polymerase chain reaction (PCR) to observer the polymorphism of ACE gene amplify by electrophoresis. ACE I/D genotype frequencies were determined for the students groups.

Result: The average age was approximately 22 years (range 18-29 years). The genotype distribution in students no athletes was 11 (18.1%) homozygous for the allele I, 41 (58.8%) heterozygous I/D, and 20 (29.2%) homozygous for the allele D.

Conclusion: These results suggest that normotensive students exposed to environmental, genetic and lifestyle factors may have influenced genetic variations that may be useful genetic markers in clinical practice.