臨床および医療ゲノミクスジャーナル

Demonstrate for the Omicron Variations Mouse Origin

Abstract

Thomas Hoenen

The question of whether SARS-CoV-2 Omicron's primary origin occurred in humans or another animal host is raised by the rapid accumulation of mutations in the virus that enabled its flare-up. Here, we identified the 45 point alterations that Omicron acquired as a result of the B.1.1 genealogy's discrepancy. A possibility of host-hopping was suggested by our discovery that the Omicron spike protein grouping was exposed to more consistent positive choice than any other reported SARS-CoV-2 variants known to grow rigorously in human hosts. Although essentially not exactly the same as the range for infections that occurred in human patients, the sub-atomic range of modifications (i.e., the total recurrence of the 12 types of base substitutions) acquired by the progenitor of Omicron appeared to match the spectrum associated with infection progression.