生物分析および生物医学ジャーナル

Comparative Disposition Kinetics of Meloxicam Following a Single Intravenous Bolus Dose and Its Concurrent Administration with Ofloxacin in Yak and Cattle

Abstract

Fakar Uddin Ali Ahmed, Rajkumar Singh Yadav and Satish Kumar Garg

Present study describes the comparative pharmacokinetic (PK) profile of meloxicam (0.5 mg.kg-1) alone its concurrent administration with ofloxacin (7.5 mg.kg-1) by intravenous route in yak and cattle. Plasma concentration of meloxicam was determined by HPLC assay and pharmacokinetic parameters by compartmental method using “PHARMKIT” software. Following intravenous administration of meloxicam alone, t1/2α, t1/2β, AUC, Vdarea and ClB values were found to be 0.21+0.04 h, 4.65+0.40 h, 25.46+1.22 μg/ml.h, 1.97+0.11 L/kg and 0.35+0.02 L/h/kg, respectively in yak and all these values were almost comparable to those found in cattle. But the values of K12/K21, Vc, Vp and fc differed significantly between yak and cattle. Further, no significant differences were observed in values of majority of the pharmacokinetic parameters between meloxicam alone or its concurrent administration with ofloxacin in yak and cattle except the values of Vc, Vp and T/P which differed significantly between alone and concurrent administration in yak but not in cattle. Based on pharmacokinetic variables, the loading and maintenance doses of meloxicam were found to be 1.05 and 0.88 mg.kg-1 body weight for yak and 0.97 and 0.79 mg.kg-1 for cattle and be repeated at 12 h interval. Results of present study further suggest that important pharmacokinetic parameters do not significantly differ between yak and cattle and meloxicam can be used at same dose levels in both the species and adjustment in dosage regimen of meloxicam is not warranted in either of the species, if to be used concurrently with ofloxacin.