核医学と放射線治療

Clinical and Morphological Factors in Evaluation of Efficacy of Facial Carcinoma Treatment by High-Energy Pulsed Neodymium Laser

Abstract

Moskalik KG, Turkevich EA, Demin EV and Kozlov AP

Purpose: In this study the influence of clinical and morphological peculiarities of facial carcinoma on the results of treatment by means of Neodymium (Nd) laser radiation was estimated.

Methods: The light of high-energy mono pulsed Nd laser (λ = 1060 nm) was used to treat 2805 patients with 2940 histologically confirmed facial carcinoma, stages T1-2 N0 M0. Of those 2845 were classified as primary basal cell carcinoma (BCC) and 95 as squamous cells carcinoma (SCC). The patients were followed-up from 1 year to 13 years (median: 7 years) after treatment.

Results: The overall frequency of tumor recurrence after laser radiation was revealed in 2% of all irradiated tumors (median: 10.0 months). The rate of recurrence depended on type of tumors (1.9% in BCC and 5.3% in SCC), clinical peculiarities (3.5% in nodular-ulcerative and 4.5% infiltrative-ulcerative tumors), localization (3.2% in tumors located in nasolabial area) and tumor size.

Conclusion: Neodymium laser radiation is an effective method for treatment of facial carcinomas stages T1-2 N0 M0 whose results depend on tumor morphology, stage of the disease, clinical characteristics and localization