心血管疾患と診断

Cardiovascular Disorders and Acetylation: Molecular Processes and Clinical Effects

Abstract

Mingjie Yang

The post-translational modification (PTM) processes that epigenetically regulate gene expression and transcriptional activity include acetylation. Reversible histone acetylation on lysine deposits administers the collaborations among DNA and histones to intercede chromatin rebuilding and quality record. Acetylation of non-histone proteins hinders cellular function, whereas acetylation of important mitochondrial enzymes controls bioenergetic metabolism. The delicate homeostatic regulation of embryonic development, postnatal maturation, cardiomyocyte differentiation, cardiac remodeling and the onset of various cardiovascular diseases like obesity, diabetes mellitus, cardiometabolic diseases, ischemiareperfusion injury, cardiac remodeling, hypertension and arrhythmias is dependent on the acetylation and deacetylation of functional proteins. Histone acetyltransferase (Caps) and histone deacetylases (HDACs) are fundamental proteins for the most part answerable for the guideline of lysine acetylation levels, accordingly giving conceivable drugable focuses to remedial mediations in the administration of cardiovascular illnesses.