法医学ジャーナル

免疫グロブリン受容体、抗原Cと慢性肝拒絶反応リスクの上昇との関連性

Abstract

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??????????????????????????????????????????????????????????????????????I????????HLA-I????????????????????NK?????????????????????????????????????????????????CR????????????????????????????????????????????????PCR-SSO???????513????????????KIR???HLA?????????????????KIR????????C?HLA-C??????KIR?????????????KIR/HLA????????????CR?n=35???????????????????NCR=478?????????????????????KIR?aKIR????????rKIR2DS2+???rKIR2DS3+???NCR?????????CR????????????????p=0.013???p=0.038???????????KIR?iKIR???????rKIR2DL2+??????????????????CR??????????9.1%?3.7%?p=0.020??KIR2DL3?CR???????????????13.1%?5.2%?p=0.008???NCR?????????????????CR?HLA-I????MM??????????????d?HLA-C2?????dC2−?????????????????CR?????????13.1%?5.6%?p=0.018?? rKIR2DL3+/dC1−?p=0.015??rKIR2DS4/dC1−?p=0.014??rKIR2DL3+/ rKIR2DS4+/dC1−?p=0.006????????????CR??????????????????5?10??????rKIR2DS1+rKIR2DS4+/dC1−??????????????????????????????????rKIR/dHLA-C???????aKIR??????CR????????????????KIR2DS1+/C1?????KIR2DS4+/C1???????????????????????????