薬経済学: オープンアクセス

ANTIHYPERLIPIDEMIC ACTIVITY OF CAMELLIA SINENSIS AND MACROTYLOMA UNIFLORUM ON HIGH FAT DIET INDUCED WISTAR ALBINO RATS

Abstract

Dhanalaxmi Mohan Raj*, K. Bhaskar Reddy

Hyperlipidemia is a disorder of lipid metabolism manifested by elevation of plasma concentrations of the various lipid and lipoprotein fractions, which is the key risk factor for cardiovascular disorders (CVD). Camellia sinensis and Macrotyloma uniflorum used as antihyperlipidemic drugs as per literature review. The aim of the present study was to evaluate the antihyperlipidaemic activity of polyherbal formulation of methanolic extract (Camellia sinensis and Macrotyloma uniflorum) in High fat diet (HFD) fed rats. Male Wistar albino rats were randomly assigned to five groups: Groups I normal control; Group II HFD control; Group III HFD+ standard drug (Atorvastatin10 mg/kg), Group IV HFD + Polyherbal methanolic extract (200 mg/kg) and Group V HFD + Polyherbal methanolic extract (400 mg/kg). The whole study lasted for 28 days. Administration of HFD caused a significant (p<0.05) rise in the serum total cholesterol (T.C), LDL-cholesterol, VLDL-cholesterol, triglycerides (T.G). Simultaneous administration of polyherbal methanolic extract of Camellia sinensis and Macrotyloma uniflorum significantly (p<0.05) prevented the rise in serum total cholesterol, LDL-cholesterol, VLDL-cholesterol, triglycerides. There was a significant decrease in body weight and increase in HDL-cholestrol was observed in polyherbal extract treated rats. Thus, the results indicate antihyperlipidaemic effect of Polyherbal formulation.