コンピュータサイエンスとシステム生物学のジャーナル

Analysis of Regulatory Genomics and Gene Expression Pattern of Medicinal Importance Genes of Helicobacter Pylori

Abstract

Pramod Katara, Ashutosh Singh, Dhwani Ragav and Vinay Sharma

Helicobacter pylori has is recognized as the main causal agent of chronic gastritis and duodenal ulcers, and it is associated with the subsequent development of gastric carcinoma. It adapted to life in a unique nice, the gastric epithelium of primates, its promoter may there for show different types of regulatory motif from those of other bacteria and it is well known fact that motif are the sequence portion which are responsible for gene regulation, by studying them we can control the expression of such genes of interest. Here, the objective of this work is to analyze the regulatory sequence pattern of virulence genes that have medicinal importance for providing a basis for drug development process and further analysis of transcriptional regulatory networks. For this purpose using available microarray gene expression data from Stanford Microarray Database, and computation tools, As a result we found that helicobacter pylori shows different type of regulatory motif of Oligo and Dyad pattern in studied genes. The most common length of single block, Oligo motif is 8 – 14, and the most common pattern for Dyad is 4 (4/8)3, we also observe that the GC content of these regulatory is just 15-20%, which is comparatively very less.