臨床症例報告ジャーナル

An Unusual but Treatable Cause of Autistic Regression

Abstract

Aarthi Balaji, M. Smilu*, M.P. Kavitha and Abraham Bose

We report the case of a seven year old male child who presented with regression of cognitive function and loss of speech over a 12 month period. Physical neurological examination was normal with no KF ring. Differential diagnoses considered were Wilson’s disease, autoimmune encephalitis and SSPE. CSF analysis was normal. EEG was non-contributory. Serum ceruloplasmin was within normal limits. Serum autoimmune panel had tested positive for CASPR2. Child was treated with pulse methylprednisolone followed by oral steroids. Child‘s cognitive function and speech have improved to a great extent.