がん臨床試験ジャーナル

A Risk Score to Evaluate the Risk of Lung Cancer in People with HIV

Abstract

Vincent J. Amoruccio, Dinesh P. Mital and Shankar Srinivasan

The advent of antiretroviral therapy (ART) changed the prognosis of HIV. People with HIV (PWH) live longer lives but are susceptible to the same age-related disease as people without HIV. Cancer is a leading cause of death for PWH, and lung cancer is the leading cause of cancer-related death. Smoking and increased age are the primary causes of lung cancer in the general population; however, risk factors specific to HIV, such as immunocompetence and respiratory disease, present additional lung cancer risk in PWH. Existing guidance from the National Lung Cancer Screening Trial (NLST) excludes PWH, does not consider HIVspecific risk factors, and misses significant amounts of lung cancer cases in PWH when it is applied. This deficiency has led to increased incidence and mortality from lung cancer and at younger ages and more advanced stages.