生物医学および薬学ジャーナル

A National Survey on the Outcome of Juvenile Immunoglobulin a Nephropathy with Acute Kidney Injury at the Onset of the Disease

Abstract

Mario Allegra

Juvenile Immunoglobulin A Nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and represents a significant cause of kidney disease in children and adolescents. This chronic kidney disorder is characterized by the deposition of Immunoglobulin A (IgA) in the glomerular mesangium, leading to inflammation and renal damage. IgAN typically presents with various clinical manifestations, but Acute Kidney Injury (AKI) at the onset of the disease is a severe and relatively rare complication that has been of growing concern in recent years. The coexistence of IgAN and AKI poses a significant clinical challenge, as it can lead to rapid deterioration in renal function and poor outcomes. There is a need for comprehensive research to understand the prognosis, risk factors, and optimal management strategies for children and adolescents with IgAN who experience AKI at the time of diagnosis. This article will delve into a national survey exploring the outcomes of juvenile IgAN patients with AKI at the onset of the disease, shedding light on the clinical characteristics, potential risk factors, and management strategies associated with this challenging scenario.